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KMID : 0882420240990020061
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Korean Journal of Medicine
2024 Volume.99 No. 2 p.61 ~ p.68
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Sodium-Glucose Cotransporter 2 Inhibitors for Chronic Kidney Disease: A Comprehensive Review
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Song Su-Hyun
Bae Eun-Hui
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Abstract
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Chronic Kidney Disease (CKD) is a major global health burden. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated potential in slowing CKD progression. We evaluated the expanding role of SGLT2 inhibitors, emphasizing their renoprotective benefits in diabetic and non-diabetic CKD patients. We also investigated the underlying mechanisms, including the reduction of glomerular hypertension via modulation of tubuloglomerular feedback. Our study critically analyzed current indications for SGLT2 inhibitor therapy based on recent clinical trial data. To optimize patient outcomes, we present a comprehensive analysis of practical considerations for the prescription of SGLT2 inhibitors, including the potential initial decline in the estimated glomerular filtration rate and a review of adverse events.
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KEYWORD
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Sodium-glucose transporter 2 inhibitors, Renal insufficiency, chronic, Albuminuria, Diabetic mellitus, Kidney protection
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